Wayne Taylor and Elisabeth Fowler
The patient-focused paradigm in healthcare began to emerge in the
early 1990’s. In 2006 the
International Association of Patient Organizations (IAPO) adopted
the Declaration on Patient-
Centred Healthcare. This study examined the degree to which the five
principles embedded in
this Declaration are being advocated and utilized in the asthma
patient-provider relationship in
five countries. The empirical evidence in this study shows that the
implementation of patientcentred care both as a policy concept and a
practice modality for asthma has not been achieved to the extent
needed. The paper makes recommendations to help patient
organizations realize the full benefits of patient-centred care.
Jonathan P. Alberding , Ronald L. Heimark , Ann L. Baldwin
The hypothesis that transient change in transmural pressure alters
F-actin and β-catenin arrangement in endothelial cells was tested. A
confluent monolayer was exposed to a transient pressure gradient (20
mmHg). Thirty minutes later, deconvolution microscopy showed the
average ratio of peripheral (at cell edge) to central (linear fibers
in cell body) F-actin had significantly increased compared to
controls not exposed to pressure (4.66 ± 4.52 (SE) vs 1.42 ± 0.35).
Beta-catenin localized at cell edges. No differences occurred when
both sides of the monolayer were pressurized simultaneously. Thus a
transient pressure gradient causes F-actin and beta-catenin
co-localization at cell boundaries.
Purpose: To establish
whether exercise training (ExT) might modify functional capacity,
quality of life (QOL), brain natriuretic peptides (BNP) and
pro-inflammatory cytokines in heart
failure (CHF) patients. Methods: 22 CHF patients, 20 men, 64.7±8.3
83±13.5(kg), left ventricular ejection fraction (LVEF) 28.6±8(%)
completed 16 weeks ExT.
Cytokines, BNP, VO2 and QOL were measured before and after ExT.
Results: After ExT
peak VO2 increased 20% from 11.6±4.7 (ml/kg/min) to 13.9±4.6
ml/kg/min (p=0.003), while
TNF-alpha, IL-1, IL-6 and BNP were unaltered. Conclusion: Functional
capacity and QOL
were improved, however pro-inflammatory cytokines and BNP were
unaltered by 16 weeks
Age-related Ultracytochemical Peculiarities of Alkaline Phosphatase
and Ca2+-ATPase Activity in Blood-Thymus Barrier
Tatyana Yu. Kvitnitskaya-Ryzhova, Svetlana P. Malysheva, Pavel V.
In this work an ultracytochemical activity of alkaline phosphatase
in capillaries and pericapillary structures in thymuses of rats have
been determined. Animals of three different age groups were
evaluated: 2 months, 7 months, and 26 months. It was shown that
activity of both enzymes reduces with the age. Average cytochemical
index of alkaline phosphatase reduces in 7-months old animals, but
this dropping tendency is observed in 26 months old animals.
Decrease of the average cytochemical indexes of
and Alkaline Phosphatase in rat thymocytes starts at the age of 7
months. Thus, the activity of both enzymes in thymus with age
reduces, which explains the degradation of the tissue and
transportation of Ca+2 ions. Accumulation of Ca+2 ions in thymocytes
may lead to their death with age.
Bioelectromagnetic Energy Fields Accelerate Wound Healing and
Activate Immune Cell Function
Lisanne D’Andrea-Winslow, Don F. Johnson, Amy K. Novitski
Bioelectromagnetic energy treatment of dermal wounds in the sea
urchin Lytechinus variegates
showed a 75.7% rate of wound closure in treatment groups compared to
41.9% in controls (t =
3.603 (df=18), p<.01). Cohen’s d yielded a strong effect on size, d
= 1.14. SDS-PAGE revealed
an increase in 101.8, 63 and 35kDa polypeptides and attenuation in
56, 43 and 32 kDa
polypeptides from wounds in treated animals compared to controls.
Immune cell activation in
treatment groups showed a 59.7% increase over controls. Taken
together, the data indicate that
biologically generated electromagnetic energy enhances and
accelerates an invertebrate wound