ISSN 1556-6757







Volume 4, Issue 1, 2013


Analysis of the Positively and Non-Positively Selected Non-Protein Coding Sequences of Human Chromosome 16

John Snedeker, Kyle Tretina, Meredith Triplet, David Lee, Anne Poirier, Pattle Pun, John Hayward, Ross Ka-Kit Leung, Stephen Kwok-Wing Tsui.  


The majority of the human genome consists of non-protein coding sequences of unknown function. Apipeline for predicting the functionality of these sequences utilizing selection algorithms from the HapMap project to identify SNPs, a mirror UCSC Genome Browser site to collect SNP flanking sequences, and finally the TRANSFAC database to discover homology to known regulatory sitesis described herein. It wasfound that around three quarters of the non-coding SNP flanking sequences of human chromosome 16 (a) mayplay a significant role in transcription regulation, and (b) are on average 5kb closer to genes than non-coding SNPs as a whole. Full Article