Prolonged inflammatory cytokine expression during the late phase of
wound healing in the diabetic K14/mIGF1 transgenic mice.
Maryna S. Shkumat, Pavlo P. Klymenko, Yuri I. Leonov, Iryna N.
numerous components of wound healing, including inflammation, matrix
deposition, and angiogenesis. The locally acting isoform of IGF-1
(mIGF-1) was shown to enhance wound healing. In this study, we
tested the therapeutic potential of mIGF-1 in the skin regeneration
of diabetic mice. To establish the mechanism of mIGF-1 transgene
action on the diabetic wound healing the effect of mIGF-1 transgene
on angiogenesis and its interrelation with the inflammatory process
in the wound was verified. Also, the total IGF-1 gene expression
damage in the uninjured skin of diabetic mice, and elevated level in
the skin of K14/mIGF-1 transgenic mice were established.