ISSN 1556-6757







Volume 6, Issue 1, 2013


Prolonged inflammatory cytokine expression during the late phase of wound healing in the diabetic K14/mIGF1 transgenic mice.

Maryna S. Shkumat, Pavlo P. Klymenko, Yuri I. Leonov, Iryna N. Pishel,
Pavel V.Glukhovskiy.

Diabetes impairs numerous components of wound healing, including inflammation, matrix deposition, and angiogenesis. The locally acting isoform of IGF-1 (mIGF-1) was shown to enhance wound healing. In this study, we tested the therapeutic potential of mIGF-1 in the skin regeneration of diabetic mice. To establish the mechanism of mIGF-1 transgene action on the diabetic wound healing the effect of mIGF-1 transgene on angiogenesis and its interrelation with the inflammatory process in the wound was verified. Also, the total IGF-1 gene expression damage in the uninjured skin of diabetic mice, and elevated level in the skin of K14/mIGF-1 transgenic mice were established. Full Article.